Candidate Genes in Adult Elderly and Adult Intermeddle Diabetes

Submit Manuscript | http://medcraveonline.com is based on the multiple pathophysiological effects involved in its pathogenesis, as well as dissection of its possible overlapping genetic component in families with DM presenting different forms of inheritance in conjunction with type 2 DM. Unfortunately it is not known, even the frequency of these overlapping positions, nor have all the phenotypes of these positions been reported [15]. Five pure forms of DM have now been reported; DM type 1, DM type 2, DM with deafness, DM onset in young adult (MODY), DM onset in older adult and neonatal DM. The first two have a multifactorial inheritance pattern, the third mitochondrial, and the last autosomal dominant [1-5]. Familial co-inheritance of DM MODY with type 2 DM results in a variant of DM onset in the neonatal stage. Families with DM2 have been reported to develop antibodies characteristic of type 1 DM, or type 2 DM with mitochondrial component. In the Mexican population DM MODY has been described with the production of antibodies characteristic of DM1. Therefore, it is essential for physicians of all levels of health care to acquire expertise to perform a dissection of the combined forms in their captive population, as this translates into differences in metabolic control [1-5].